The Brain of Cthulhu is the Crimson counterpart to the Eater of Worlds. Defeating the Brain of Cthulhu for the first time allows the Tavernkeep NPC to spawn. All Creepers must be destroyed first before the Brain of Cthulhu enters its second phase, where it becomes vulnerable to attack and can be killed.ĭefeating the Brain of Cthulhu and its attendant Creepers is the only way to obtain Tissue Samples, and is one of the ways to obtain usable quantities of Crimtane Ore. Creepers do not respawn once they are killed. 20 Creepers spawn along with the Brain and orbit the boss at high speed. ![]() In the first, the Brain is invulnerable and teleports randomly around the player. It can be summoned when 3 Crimson Hearts are destroyed in a Crimson world, or when a player uses a Bloody Spine anywhere in The Crimson or Underground Crimson biome. ![]() ![]() The Brain of Cthulhu is a pre-Hardmode, Crimson-themed boss resembling a large, flying brain. For the Old-gen console, Windows Phone, and 3DS pet summon, see Brain.
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